Fertilizers enhance crop productivity but can pose health risks, especially for agricultural workers and individuals with pre-existing conditions. Exposure can lead to skin irritation, respiratory problems, infections, or more severe conditions like chemical burns or systemic toxicity—such reactions are collectively known as fertilizer sensitivity. Treating fertilizer sensitivity depends on exposure route and intensity, and some methods of treatment include topical medications, inhalers, emergency care, and long-term avoidance. Fertilizer sensitivity prevention emphasizes using personal protective equipment (PPE) in a consistent manner, safe handling, proper storage, and application in well-ventilated areas that are away from living spaces and food sources. Providing people with Safety Data Sheets (SDSs) and training through employers can also reduce risks of developing fertilizer sensitivity. For people with fertilizer sensitivity, recognizing symptoms of fertilizer sensitivity early and following up with healthcare providers are essential steps to managing and preventing complications. In a broader sense, protecting our communities from the health dangers of fertilizers calls for promoting and understanding safe use and storage of fertilizers in both workplace and home gardening practices.